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Longitudinal comparison of lung UTE-MRI and CT

Longitudinal comparison of quantitative UTE lung MRI and CT biomarkers in interstitial lung disease

by Ho-Fung Chan, Timothy J Baldwin, Harry Barker, Neil J Stewart, James A Eaden, Paul J.C Hughes, Nicholas D Weatherley, Joshua Astley, Bilal A Tahir, Kevin M Johnson, Ronald A Karwoski, Brian J Bartholmai, Marta Tibiletti, Colm T Leonard, Sarah Skeoch, Nazia Chaudhuri, Ian N Bruce, Geoff J.M Parker, Stephen M Bianchi, and Jim M Wild

ISMRM 2022 conference abstract

UTE lung MRI approaches the diagnostic quality of CT, opening up the possibility for longitudinal follow-up of interstitial lung disease (ILD) progression. Two quantitative biomarkers of UTE lung signal were developed for monitoring longitudinal change in ILD and benchmarked against quantitative CT CALIPER measurements. Normalized UTE lung signal and UTE high percentage (based on 95% cutoff of healthy UTE lung values) was significantly different between nine healthy volunteers and sixteen ILD patients. Longitudinal change in UTE biomarkers correlated with change in CT CALIPER ILD% in the ILD patients, and most-strongly correlated to CT ground-glass changes in the lung parenchyma.