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Conference Abstract: IL-2 PET

Development and evaluation of a new Interleukin-2 PET radioligand Al[18F]RESCA-IL2: comparison with [18F]FB-IL2

I.F. Antunes, E.L. van der Veen, E.E.M. Deneer, F. Cleeren, G. Bormans, P.H Elsinga, R.A.J.O. Dierckx, E.G.E de Vries, E.F.J. de Vries


31st Annual Congress of the European Association of Nuclear Medicine, 13-17 October 2018, Düsseldorf

 

Aim

Interleukin-2 is a 15.5 kDa glycoprotein that binds with high affinity to IL2 receptors (IL2R) that are overexpressed on activated T-cells, which are involved in various pathological diseases, such as autoimmune diseases, but also play a major role in the tumor immune response. We have developed [18F]FB-IL2 which has been successfully used for detecting activated T-cells in rodents [1]. Recently, a GMP-compliant production of [18F]FB-IL2 for clinical use was implemented, but the production method proved to be complex and time-consuming. Therefore, we now developed a simplified method to label IL2 with 18F. Here we present the synthesis of Al[18F]-RESCA-IL2 and its comparison to [18F]FB-IL2.